As you may know this Novel Corona Virus does not have the same mortality rate in children as it does in adults. It seems as though children have been spared the worst of the effects of this virus. We have to ask ourselves why is this? I have looked into it a bit and what I have found is that this virus specifically causes our immune systems to have an exaggerated response, which we call a cytokine storm. As Amy Mckeever published in the National Geographic on February 18,2020. She explains how the cytokine storm effects our lungs and our entire body.

Cytokines are proteins used by the immune system as alarm beacons—they recruit immune cells to the site of infection. The immune cells then kill off the infected tissue in a bid to save the rest of the body.

Humans rely on our immune systems to keep their cool when facing a threat. But during a runaway coronavirus infection, when the immune system dumps cytokines into the lungs without any regulation, this culling becomes a free-for-all, Rasmussen says “Instead of shooting at a target with a gun, you’re using a missile launcher,” she says. That’s where the problem arises: Your body is not just targeting the infected cells. It is attacking healthy tissue too.

The implications extend outside the lungs. Cytokine storms create inflammation that weakens blood vessels in the lungs and causes fluid to seep through to the air sacs. “Basically you’re bleeding out of your blood vessels,” Rasmussen says. The storm spills into your circulatory system and creates systemic issues across multiple organs.

Could it be that the cytokine response difference in children vs adults could explain the difference in mortality rate of pediatrics vs adults?

It has been found that there is a significant difference in the cytokine response between children and adults. It seems that children have a much more mild slow building cytokine response in comparison to adults. They are not susceptible to the initial cytokine storms that many adults seem to face. I was very curious as to the differences and read this article that I will link here. The study I linked here was conducted on burn patients and was to measure the differences between cytokine responses in adults vs pediatrics. The different expressions of 18 cytokines were studied. It seems as though adults have an initial elevated cytokine response, where as children do not have that same dramatic initial response. In children it rises slowly over time.

It has been clearly established that cytokine storms have been responsible for a large number of adult fatalities with this current virus. This would include those who have contracted or re-contracted Covid-19, and suddenly died or dropped into a coma, as well as those who succumb to runaway viral pneumonia. My next logical thought is, “Can we do something about this?”. Is it possible that there are methods for reducing the initial response of the cytokine proteins?

This is something that would need to be contemplated and studied. In fact there are many natural approaches that a person can take to inhibit the cytokine response in the body. But clearly this would not be the best step for everyone. The protocol would be different dependent upon age and health variations.

Could we come up with measures that people can take accordingly? I believe it is possible. Could it be that this particular deadly virus can be beat with something as simple as a vitamin C? Something else to consider is the mortality rate differences in different nations. Consider that the diet from one nation to the next is different. Could it be that certain natural foods in the diet are responsible for increasing the cytokine response, while others inhibit it? Yes it is.

As we know South Korea is currently experiencing a severe outbreak, but their mortality rate remains low. What is different in their diet as compared to others. They do have a diet high in vitamin C, as you will see here in this beauty article that discusses how their diet is attributed to their beauty. Could beating this invisible killer be so simple?

What we currently know is that there are a variety of different natural antivirals and some of them have a specific difference, some of them promote the cytokine response and some inhibit it. Could it be that China has already figured this out? It is known that there has been little success in China with antivirals. They are now conducting a new study injecting patients with high doses of vitamin C. The one difference that this anti-viral has with others is that it inhibits the cytokine response.

What if we took these according to our needs before we contracted this virus? Would the outcome be different? Would our cytokine response be the same, or would it be different? Is there a possibility that it could render this virus more mild by changing our bodies response to the virus, and decrease the fatality rate?

Keep in mind I am not declaring that anything I propose is a cure. What I am proposing is giving our body an advantage in advance to help fight off the virus, or to help prevent the potentially deadly effects of a cytokine storm.

Here I will discuss the different natural antivirals and how they affect the cytokine response in the body.

The first is Vitamin D, it has been proven that Vitamin D inhibits or lowers cytokine production. A study was conducted on cells with a low value, and one with a higher value of the vitamin, the one with lower value produced more cytokines, in this study specifically, TNF-a and IL-6, these are the cytokines responsible for the inflammatory response.

As you will see in this article, taking vitamin D can inhibit cytokine production.

Vitamin C is important for immune function, and is a powerful antioxidant. It has been proven to lower the body’s inflammatory cytokine response.

Vitamin C has been shown to speed up the recovery time of critically ill patients, in intensive care. It is notable to state that it has also been shown that most critical care patients have very low C plasma levels.

Green Tea has been shown to inhibit cytokine production in laboratory studies. It is said to inhibit production of TNF-a and IL-6.

Ginger has been shown to suppress pro inflammatory cytokine TNF-a.

Vitamin E therapy has been shown to decrease pro-inflammatory cytokines, such as TNF-a and IL-6 in patients with cardiovascular disease.

Garlic might cause the downregulation of pro-inflammatory cytokines. Garlic compounds could act as immunomodulatory agents. It can enhance the anti-viral immune response. Inflammatory cytokine production is reduced significantly in the presence of garlic extract or its compounds revealing potential therapeutic use.

As mentioned here I have listed just a few of the natural antivirals that also inhibit pro-inflammatory cytokines. Now I will cover a few of the different natural antivirals that are thought to promote cytokines, which could have deadly adverse reactions with the coronavirus, considering that most of the fatalities have been caused by cytokine storms, and the resulting inflammation.

The first I will cover is Elderberry. This has long been known to fight colds and flu’s in a powerful way. What we need to keep in mind is that this corona virus is not the flu. Elderberry increases cytokines up to eightfold. This could potentially be deadly with this coronavirus.

Echinacea is a powerful antiviral, however use during coronavirus infection could be counter productive due to the fact that it increases cytokine production.

Honey is said to induce the maximum cytokine response.

The information I have compiled in this article is incomplete. I want to get this information out based on my assumptions. This clearly needs the advice and study of professionals. It is possible there could be something to this hypothesis? Is there a possibility that we could use natural foods and simple low dose supplements to stop the severe effects of this virus?

We need professionals to come together and study this. If this has any potential we need to know what the proper dosages are for certain age groups and people with certain health conditions as one size clearly does not fit all. We also need to know what remedies can be combined. Is it possible that where some remedies could be harmful and  potentially increasing cytokines could be beneficial when taken with others that decrease the production? I am not a professional so I don’t know. I would love for this to be studied. If there is any validity to this hypothesis, we could save countless lives in the simplest of ways.

I will end this article with one more interesting observation. There is one  article worthy of note written by Randy Cron M.D, P.h.D, Professor of Pediatrics & medicine at UAB. In this article he writes that 10 to 15% of the population has a genetic mutation that pre-disposes them to develop cytokine storms. This somewhat coincides with some of the unofficial fatality rates for Covid-19. It would not be so strange that the real killer in this story is the actual cytokine responses in patients, and not the virus itself.  And the same percentage of the population that may have a genetic defect that predisposes them to having a cytokine storm may match the unofficial, but suspected, death rates, and  may be a clue to stopping this pandemic in it’s tracks.

UPDATE: Since posting this study, I have completed a more in depth compilation with more compelling evidence. I am also in the process of posting a third study that covers compounds with linked studies that have been proven to be powerful cytokine modulators and inhibitors. The studies have proven that in certain cases if taken in advance of a known onset of increased cytokine production to be successful at inhibiting that response. The question is could this work with this Novel Coronavirus. We need the voice of experts to weigh in on this, it deserves to be investigated. If the hypothesis is correct it could potentially save many hundreds of thousands or millions of lives.

Thank you to all who have taken the time to read this.

 

This article has 6 comments

  1. doctor

    A fall in ACE2 activity in the elderly is partly to blame for humans poorer ability to put the brakes on our inflammatory response as we age, according to emailed comments from Hongpeng Jia of Johns Hopkins Medicine. Reduced abundance of ACE2 receptors in older adults could leave them less able to cope with SARS-CoV-2, says Baric, though the hypothesis still needs more research. There are four other coronaviruses that infect humans, with symptoms typical of a common cold. These viruses are common in children. We don t know which of them, if any, might provide some cross immunity, says Subbarao. It could be that immunity to viral proteins, obtained from circulating common cold viruses, moderates the course of COVID-19.

    • Justice

      Certainly the ACE2 receptors play a major role. I have read several studies on the ACE2. In this theory I was solely focusing on the cytokine aspect. It is multifaceted and certainly this would have to be taken into consideration as a whole in combination with all other factors. This is clearly only a small piece of the puzzle. Thank you for your informative and valid comment, it is greatly appreciated.

      As I have understood it thus far those who have more ACE2 receptors could be at greater danger, the virus has an affinity and binds with the ACE2 receptors. That is the entry point into the body. This can cause a greater viral load.

      Thank you for the comment and the information.

  2. Pamela Hubbard

    There is a very old recipe that survivors of the 1918 pandemic swore by which includes your recommended food sources. I’ve made this recipe for many years, myself, and it does prevent many colds, food poisoning, stomach viruses, etc.: I use a food processor but you could grate equal weights of the following 5 ingredients: fresh garlic, fresh habanero peppers, fresh white onion, fresh ginger root, fresh horseradish root. Cover it with apple cider vinegar and stir ingredients together. Put in a dark place and let sit for two weeks, covered, stirring a few times or so. Then it is ready to strain through a cheese cloth and can be taken as needed. One tablespoon at a time in tomato juice tastes great or if you are very tough, put into a little water or take full strength for the most punch. It’s quite potent and after reading your article I see why it works. 🙂 Thank you for this very interesting read. By the way, use gloves, eye glasses and possibly a mask. These ingredients are not for the faint of heart and those peppers can be irksome to your hands while the horseradish root vapors to me are the strongest upon mincing. ikes Oh, and be sure to use glass containers and not plastic. Plastic lids are best though so don’t fill quite to the tops of the jars. Keeps forever.

    • Justice

      Wonderful recipe Pamela. Thank you for reading, and thank you so much for sharing that amazing recipe. I will find it and post it to this site. I will give that one a go. It sounds very similar to the flu bomb recipe. I have that video linked at the bottom of the page. Because of the recipe in this video, I haven’t had a full blown flu or cold in over three years. It works. Here is the link.

  3. robert

    Correct me if I’m wrong, but your proposing that vitamin d, high dose vitamin C, garlic, ginger, green tea may prevent corona (or its response you talk about). Can you give dosage info for vitamin C? I drink green tea throughout the day, every day. Drinking ginger/garlic/cayenne pepper drinks (made with juicer) daily….

    • Justice

      Thank you for taking the time to read my hypothesis, and for your reply. Honestly I don’t really feel qualified to give any real advice on this one. Mostly I wrote this so that it could be studied by medical experts who could see if there was any validity to the hypothesis and to give us their recommendations on what doses we should take. 

      Here’s what I do know is that in China They are giving those high doses to the most ill who are on ventilators. They are asking their citizens to supplement. I do not know what dosages they are recommending. 

      I can’t give any real advice but I know for me personally I don’t feel comfortable with high dosing on anything. I wouldn’t consider that unless I knew I had actually contracted the virus. As for now I feel for myself just taking a basic dose is better than nothing. On any given day I take 500 to 1000mg of vitamin C. On a side note, this should be taken with magnesium as it can deplete your magnesium. 

      One of the safest ways to get vitamin C is in your diet. Here is a list of foods high in vitamin C

      As for vitamin D, make sure it is D3 with K2 in it. The K2 helps the calcium to go to your bones. Taking vitamin D without the K2 can cause calcium build up in your soft tissues. I myself take 5K IU’s, but not every single day. The best way of all to get your vitamin D is 15 to 20 mins a day in the sunshine. Nothing beats that version. But if you cant there is always supplementation.

      I apologize for not being able to give better advice. This article was written based on a hypothesis. It is a plea to the experts to study it and give us the advice. 

      I do not know the validity of it. It certainly needs further investigation. I do not believe it would work for everyone. It would be nice if it worked for many though. My hypothesis is that it can help to prevent the cytokine storm which is what is killing people who contract the virus. My hypothesis is that if we inhibit those cytokines that it will prevent the deadly effects of the virus. 

      Thank you so much for taking the time to read this. All the best, and stay safe out there. 

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